Brain Plasticity and the Stability of Cognition
Overview
Background to two of our models
TraceLink model
TraceLink model: structure
System 1: Trace system
System 2: Link system
Location of the hippocampus
System 3: Modulatory system
Stages in episodic learning
How does consolidation work in a TraceLink?
Sleep-consolidation hypothesis
Selfrepairing neural networks
Redundancy and repair
Redundancy and repair example
This process has a long life-time
Application
PPT Slide
Studies in cognitive neurosciene
From brain to behavior
The problem
Detail and abstraction
Principles of multi-level modeling
Multi-level modeling in cognitive neuroscience
Additional levels can be considered as well
Multi-level modeling in the PIONIER group
Level 1. Mathematical models
Level 2. High-level computational models
Level 3. Low-level computational models
Illustration of different levels of modeling in our group
TraceLink as a starting point (level 2 model)
Extensions of TraceLink (level 2)
Detailing TraceLink (level 3)
Example of a level 3 model
Formation of long-range connections in the cortex
Based on the work of Abeles: so called synfire chains
Simulations
Main characteristics of the development of synfire chains
Example of level 1 model
Abstracting TraceLink (level 1)
Learning and forgetting as a stochastic process
Some aspects of the point process model
Hellyer (1962). Recall as a function of 1, 2, 4 and 8 presentations
Retrograde amnesia (RA)
Albert et al. (1979), naming of famous faces
Example of multi-level approach
Learning associations between aspects of an experience
Obtaining data to model
Obtaining data to model: quantitative neuroanatomy
Obtaining data to model: retrograde amnesia (RA)
Direct investigation of consolidation: sleep experiment
Research infrastructure and knowledge management
Infrastructure for research and knowledge management
Neurosimulation software developed by us: Walnut and Nutshell
Dissemination of results
Dissemination of results (cont'd)
Preservation and exchange of knowledge within the group
Concluding remarks
Modeling in a multi-discipline
Steps towards the goal
Email: jaap@murre.com
Home Page: http://www.neuromod.org/publications/
Other information: neuroMod: Home of the Neural and Cognitive Modeling Group at the University of Amsterdam.
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