Methods and models
Last week
This week
Structural methods
Magnetic Resonance Imaging (MRI)
Computed Tomography (CT)
Functional methods
Data by Matt Wilson and Bruce McNaughton (1994)
Wilson en McNaughton Data
Temporal and spatial resolution
Het geheugen is opgeslagen in de verbindingen (synapsen) tussen de neuronen
Voorbeeld: Alzheimer's dementie
Alzheimer's dementie
Amnesie bij Alzheimer's
Alzheimer's dementie komt zeer veel voor
Wat is Magnetic Resonance Imaging (MRI)?
MRI van het brein: bij Alzheimer is het brein duidelijk verschrompeld
Vergelijk de centrale sulcus van de Alzheimer's patient met die van een gezonde 81 jarige vrouw
Met name de hippocampus is verschrompeld bij Alzheimer's dementie
74 jaar oude patient met Alzheimer's dementie: Verminderde doorbloeding op de SPECT (rechts) in temporale gebieden
Models: An intermediary level between theory and experiment
Examples of different neural network models
Neural networks
Neural networks abstract from the details of real neurons
Example 1: Generating complex behavior by very simple creatures
Karl Sims' Virtual creatures
Example 2: Willshaw networks
Example of a simple heteroassociative memory of the Willshaw type
Example of pattern retrieval
Example of successful pattern completion using a subpattern
Example graceful degradation: small lesions have small effects
Summing up
Example 3: (Very) simple visual processing
PPT Slide
Example 4: The TraceLink model of amnesia
Some important characteristics of amnesia
An example of retrograde amnesia patient data
Trace-Link model: structure
Stages in episodic learning
Retrograde amnesia
Next week...
Email: jaap@murre.com
Home Page: http://www.neuromod.org/courses/local.html
Other information: neuroMod: Home of the Neural and Cognitive Modeling Group at the University of Amsterdam.
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